Prescribing Information for:KliovanceKliofemNovofemTrisequensVagifem

Prescribing Information for:KliovanceKliofem

NovofemTrisequensVagifem

HRT Products

A Guide To Novo Nordisk
Hormone Replacement Therapies

Kliovance®

1mg oestradiol + 0.5mg norethisterone acetate 

oral tablets1

Oestrogen/progestagen
Estradiol 1mg, norethisterone 0.5mg
(white tablet)

Type
Continuous combined

Bleed
No bleed**

Intact uterus*
Yes

Tablet break
No

Time since last menses
12 months
Transition from continuous combined or not taking HRT
Start on any convenient day
Transition from sequential HRT
Start right after withdrawal bleed has ended
Dosing
1 tablet daily without interruption

Kliofem®

2mg oestradiol + 1mg norethisterone acetate 

oral tablets2

Oestrogen/progestagen
Estradiol 2mg, norethisterone 1mg
(white tablet)
Type
Continuous combined

Bleed
No bleed**

Intact uterus*
Yes

Tablet break
No

Time since last menses
12 months
Transition from continuous combined or not taking HRT
Start on any convenient day
Transition from sequential HRT
Start right after withdrawal bleed has ended
Dosing
1 tablet daily without interruption

Novofem®

1 mg oestradiol + 1 mg norethisterone acetate 

oral tablets3

Oestrogen/progestagen
Estradiol 1mg
(red tablet)

Norethisterone 1mg, estradiol 1mg
(white tablet)

Type
Sequential combined
Bleed
Monthly
Intact uterus*
Yes

Tablet break
No

Time since last menses
6 months
Transition from continuous combined or not taking HRT
Start on any convenient day
Transition from sequential HRT
Begin the day following completion of preceding regimen
Dosing
1 red tablet for 16 days, followed by 1 white tablet for 12 days without interruption

Trisequens®

2mg/2mg/1mg oestradiol + 1mg norethisterone acetate 

oral tablets4
Oestrogen/progestagen
Estradiol 2mg
(blue tablet)

Estradiol 2mg, norethisterone 1mg
(white tablet)

Estradiol 1 mg
(red tablet)

Type
Sequential combined
Bleed
Monthly
Intact uterus*
Yes

Tablet break
No

Time since last menses
6 months§
Transition from continuous combined or not taking HRT
Start on any convenient day
Transition from sequential HRT
Begin the day following completion of preceding regimen
Dosing
1 blue tablet for 12 days, followed by 1 white tablet for 10 days, followed by 1 red tablet for 6 days without interruption

References:
1. Kliovance® Summary of Product Characteristics. 2. Kliofem® Summary of Product Characteristics. 3. Novofem® Summary of Product Characteristics. 4. Trisequens® Summary of Product Characteristics.

HRT: Hormone Replacement Therapy
*Suitable for patients with intact uterus
**Breakthrough bleeds may occur during the first months of treatment
Kliovance® is indicated for Hormone Replacement Therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women with more than 1 year since last menses.
Kliofem® is indicated for Hormone Replacement Therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women with more than 1 year since last menses.
Novofem® is indicated for Hormone Replacement Therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women with at least 6 months since last menses.
§Trisequens® is indicated for Hormone Replacement Therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women with at least 6 months since last menses.

This is a Novo Nordisk® website intended for UK healthcare professionals

Date of preparation: July 2020  UK20VG00009   Privacy Policy   Contact us

This is a Novo Nordisk® website intended for healthcare professionals

Date of preparation: July 2020
UK20VG00009
Privacy Policy   Contact us